The 365 Elite Health Check

Full Blood Count

Haemoglobin — oxygen-carrying capacity of the blood Haematocrit — proportion of red blood cells in total blood volume RBC — total red blood cell count WBC — total white blood cell count and immune activity Neutrophils — first-response immune cells, elevated in infection or inflammation Lymphocytes — adaptive immune cells including T and B cells Monocytes — immune cells involved in chronic inflammation Eosinophils — markers of allergic response and parasitic infection Basophils — rare immune cells involved in allergic reactions Platelets — clotting function and bleeding risk MCV — average red blood cell size, key for anaemia typing MCH — average haemoglobin per red cell MCHC — haemoglobin concentration within red cells RDW — variation in red cell size, early anaemia and inflammation signal ESR — non-specific inflammation marker, elevated in infection, autoimmune, and malignancy Fibrinogen — clotting protein and cardiovascular inflammation marker IL-6 — pro-inflammatory cytokine, elevated in chronic disease and metabolic dysfunction

Metabolic

Fasting glucose — baseline blood sugar and diabetes screening HbA1c — average blood sugar over the past 3 months Fasting insulin — early insulin resistance before glucose becomes abnormal HOMA-IR — calculated ratio of insulin resistance from glucose and insulin

Lipids and Cardiovascular

Total cholesterol — overall cholesterol load LDL — primary carrier of cholesterol to tissues, key cardiovascular risk marker HDL — protective cholesterol, higher is better Triglycerides — blood fat levels linked to metabolic syndrome and cardiovascular risk ApoB — the most accurate single marker of cardiovascular particle risk ApoA1 — the primary protein in HDL, protective cardiovascular marker Lp(a) — genetically inherited cardiovascular risk factor, largely independent of lifestyle Homocysteine — amino acid elevated by B vitamin deficiency and cardiovascular risk

Comprehensive Chemistry

Sodium — fluid balance and kidney function Potassium — heart rhythm and muscle function Chloride — acid-base balance Bicarbonate — lung and kidney regulation of blood pH Creatinine — kidney filtration waste product Urea — protein metabolism and kidney clearance eGFR — estimated kidney filtration rate Bilirubin — liver processing of red blood cell breakdown ALT — liver cell damage marker, most sensitive for hepatitis AST — liver and muscle damage marker GGT — liver stress, alcohol use, and bile duct function ALP — bone and liver enzyme, elevated in disease of either Albumin — liver synthetic function and nutritional status Total protein — overall protein production and nutritional health Calcium — bone health, nerve and muscle function Phosphate — bone mineralisation and kidney health Uric acid — gout risk and metabolic health marker

Kidney

Cystatin C — more sensitive than creatinine for early kidney decline

Thyroid

TSH — pituitary signal to the thyroid, primary screening marker Free T3 — active thyroid hormone at tissue level Free T4 — thyroid hormone before conversion to T3 Reverse T3 — inactive T3, elevated under stress and chronic illness Anti-TPO — autoimmune attack on the thyroid enzyme Anti-Thyroglobulin — autoimmune attack on thyroid protein

Hormones

Total testosterone — overall testosterone production Free testosterone — biologically active testosterone available to tissues SHBG — protein that binds testosterone, affects availability Oestradiol — primary oestrogen, important in both men and women Progesterone — key female hormone, low in luteal phase defects DHEA-S — adrenal androgen, declines with age and chronic stress Cortisol — primary stress hormone, elevated in HPA axis dysfunction Prolactin — pituitary hormone, elevated in stress, medication, or tumour LH — pituitary signal driving testosterone and ovulation FSH — pituitary signal for sperm and egg production

Iron Studies

Serum iron — circulating iron available for use Ferritin — stored iron, low in deficiency, high in inflammation or overload Transferrin — iron transport protein Transferrin saturation — percentage of transferrin carrying iron TIBC — total iron binding capacity, reflects iron stores

Vitamins and Nutrients

Vitamin D — bone health, immune function, mood, and hormone production Vitamin B12 — nerve function, red blood cell production, and methylation Folate — DNA synthesis and methylation, critical in pregnancy Zinc — immune function, wound healing, testosterone production Copper — enzyme function, iron metabolism, connective tissue health Selenium — antioxidant defence, thyroid function, immune health Manganese — bone formation, metabolism, and antioxidant enzyme activity

Cancer Markers

PSA — prostate-specific antigen, screening marker for prostate health (males) CA-125 — ovarian cancer screening marker (females) CEA — carcinoembryonic antigen, broad cancer and inflammation marker

Autoimmune

ANA — antinuclear antibody, broad screen for autoimmune conditions Rheumatoid factor — elevated in rheumatoid arthritis and other autoimmune disease Anti-CCP — highly specific marker for rheumatoid arthritis