Which tests are included?
Original price was: $799.00.$599.00Current price is: $599.00.
The Genetic Methylation Test (Methylation Profile) is an advanced blood test that evaluates key markers involved in the body’s methylation cycle.
It measures functional methylation activity and folate metabolism, providing insight into how effectively your body produces and utilises methyl groups.
Which tests are included?
Why choose this test?
Methylation is a fundamental biochemical process involved in DNA regulation, detoxification, neurotransmitter balance, hormone metabolism and energy production.
The Methylation Profile is a specialised blood test that assesses the methionine and folate pathways responsible for generating methyl groups in the body.
At the centre of this process is S-Adenosyl Methionine (SAMe), the body’s primary methyl donor. As SAMe releases methyl groups, it converts to S-Adenosyl Homocysteine (SAH). The balance between these two markers reflects overall methylation efficiency.
This test measures:
SAMe
SAH
SAM/SAH Ratio (Methylation Index)
Tetrahydrofolate (THF)
Folinic Acid (5-formyl THF)
5-Methyl Tetrahydrofolate (5-MTHF)
The included pathway diagram (see report page 4) illustrates the interaction between methionine, homocysteine, folate metabolism and glutathione production.
This profile is often considered when investigating:
MTHFR-related functional concerns
Impaired methylation activity
Elevated homocysteine
Detoxification challenges
Neurotransmitter balance and sleep regulation
This is a blood test performed through an accredited laboratory.
About these tests
S-Adenosyl Methionine (SAMe)
The body’s primary methyl donor. Required for DNA/RNA synthesis, glutathione production, CoQ10 synthesis, creatine formation and neurotransmitter regulation.
S-Adenosyl Homocysteine (SAH)
Formed after SAMe donates a methyl group. Elevated SAH can inhibit methylation processes.
SAM/SAH Ratio (Methylation Index)
Reflects overall methylation efficiency. A lower ratio suggests reduced methylation activity.
Tetrahydrofolate (THF)
The basic reduced form of folate from which other active folate forms are derived.
Acid (5-formyl THF)
An active reduced folate form that can be converted into other active folates and supports methylation pathways.|
5-Methyl Tetrahydrofolate (5-MTHF)
The primary circulating folate form used to donate methyl groups to homocysteine. Its production is influenced by MTHFR enzyme activity.
No GP appointment required.
Whether you’re tracking symptoms or just want peace of mind, you’re in control.
You’ll know exactly where you stand.
No GP consult or telehealth appointment needed.
We instantly generate your pathology referral and send it directly to your inbox.
Yes you’re in full control. Pick the test you want, order in minutes, and we’ll handle the rest securely.
100%. We partner with NATA-accredited labs the same trusted labs used by hospitals and GPs.
Our tests are privately billed, which means they’re not covered by Medicare or private health insurance.
This allows you to access testing without needing to meet eligibility criteria or wait for a GP referral.
No referral needed!
After checking out, you’ll receive your PDF pathology request form instantly through email. It’s all included in the price, so you can get tested straight away without needing to visit your GP first.
Never. The price you see includes everything referral, testing, processing, and results. No surprises.
Yes, absolutely. You can build your own panel by choosing from our wide range of individual tests. Whether you’re checking one thing or a combination of markers, you’re in control of what you get tested for.
Thousands of Australians trust us to make blood testing fast, easy, and stress-free.
Methylation is a fundamental biochemical process involved in DNA regulation, detoxification, neurotransmitter balance, hormone metabolism and energy production.
The Methylation Profile is a specialised blood test that assesses the methionine and folate pathways responsible for generating methyl groups in the body.
At the centre of this process is S-Adenosyl Methionine (SAMe), the body’s primary methyl donor. As SAMe releases methyl groups, it converts to S-Adenosyl Homocysteine (SAH). The balance between these two markers reflects overall methylation efficiency.
This test measures:
SAMe
SAH
SAM/SAH Ratio (Methylation Index)
Tetrahydrofolate (THF)
Folinic Acid (5-formyl THF)
5-Methyl Tetrahydrofolate (5-MTHF)
The included pathway diagram (see report page 4) illustrates the interaction between methionine, homocysteine, folate metabolism and glutathione production.
This profile is often considered when investigating:
MTHFR-related functional concerns
Impaired methylation activity
Elevated homocysteine
Detoxification challenges
Neurotransmitter balance and sleep regulation
This is a blood test performed through an accredited laboratory.
S-Adenosyl Methionine (SAMe)
The body’s primary methyl donor. Required for DNA/RNA synthesis, glutathione production, CoQ10 synthesis, creatine formation and neurotransmitter regulation.
S-Adenosyl Homocysteine (SAH)
Formed after SAMe donates a methyl group. Elevated SAH can inhibit methylation processes.
SAM/SAH Ratio (Methylation Index)
Reflects overall methylation efficiency. A lower ratio suggests reduced methylation activity.
Tetrahydrofolate (THF)
The basic reduced form of folate from which other active folate forms are derived.
Acid (5-formyl THF)
An active reduced folate form that can be converted into other active folates and supports methylation pathways.|
5-Methyl Tetrahydrofolate (5-MTHF)
The primary circulating folate form used to donate methyl groups to homocysteine. Its production is influenced by MTHFR enzyme activity.
Measures core methylation markers (SAMe, SAH, ratio)
Assesses functional folate metabolism
Provides insight into methylation efficiency
Includes detailed pathway interpretation
Suitable for MTHFR-related functional assessment
Performed by Nutripath, NATA accredited laboratory
Blood-based testing for direct biochemical measurement
1. Receive your referral instantly after purchase
2. Quick blood test at your local collection centre
3. Results to your inbox within 1-2 days