The genetic test that determines how your body processes folate, B12 and homocysteine. Skip the GP, walk in, and get answers that inform your supplements for life.
MTHFR is the gene that codes for an enzyme central to methylation. Two common variants, C677T and A1298C, can reduce that enzyme's activity by 30 to 70 percent. The result: folate, vitamin B12 and homocysteine all get processed less efficiently. Knowing your MTHFR status changes which forms of these nutrients actually work for your biology.
Australians estimated to carry at least one MTHFR variant, based on population genetic studies. Most will never know without testing.
The process behind energy, mood, detox, DNA repair and cardiovascular health. MTHFR is the gene that runs it.
Genetic, doesn't change. One test informs your folate, B12 and B-vitamin supplement strategy for life.
With MTHFR variants, regular folic acid converts poorly. The test reveals whether you need methylfolate and methylated B vitamins instead.
If your blood work has come back with elevated homocysteine that can't be easily explained, MTHFR is one of the most common genetic reasons. Knowing your variants reveals whether your folate metabolism is part of the picture.
If a close relative has had premature cardiovascular disease or a venous thrombosis, MTHFR is part of the personal risk picture. Knowing your variant status informs your prevention conversations.
MTHFR variants are one of several factors investigated alongside recurrent miscarriages or when planning ahead. Knowing your status helps shape the folate approach worth taking.
If your folate or B12 isn't doing much, MTHFR variants are often the reason. Knowing your status reveals which methylated forms could actually land for you.
MTHFR is the genetic blueprint behind how your body uses folate, B12 and homocysteine. Once you know your status, you can stop guessing whether your supplements are landing and choose the forms that actually work for your biology.
Real reviews from Australians who tested their MTHFR gene status privately.
Wanted to dial in my supplement stack properly and a friend mentioned MTHFR testing. Did it through MediTests, no GP needed, sample collected the next morning. Found out I'm heterozygous for C677T. Swapped to methylfolate and noticing the difference already.
Verified reviewHad elevated homocysteine for years and never had the genetic side looked into. Did the MTHFR test through MediTests, found I'm heterozygous for C677T. Switched to methylfolate, my homocysteine dropped on the next retest.
Verified reviewMy sister has both MTHFR variants and suggested I test myself. It's not something routinely offered through standard pathology, so I went through MediTests instead. Came back with one C677T variant. Useful information for the long term.
Verified reviewFunctional doctor recommended MTHFR testing to fine-tune my supplement regime. MediTests was the easiest route, no consult needed, results came back in just under a week. Now I'm on methylfolate instead of folic acid and noticing the difference.
Verified reviewBeen taking B vitamins for years without much effect. Tested MTHFR through MediTests, came back with both variants. Made sense why standard folic acid wasn't working. Now I know what to actually take.
Verified reviewHeard about MTHFR from a longevity podcast and wanted to know my status. MediTests made it dead simple, no appointment, no GP, walked into a collection centre after work, results back within a week or so. Genuinely useful information.
Verified reviewThe MediTests MTHFR Blood Test checks for both of the most common variants. Together, they reveal whether your methylation enzyme is running at full capacity or reduced.
The most studied MTHFR variant. People with one copy (heterozygous) have around 30 to 40 percent reduced enzyme activity. Those with two copies (homozygous) have up to 70 percent reduced activity. C677T is most strongly linked to elevated homocysteine and cardiovascular implications.
What it tells youThe second most studied MTHFR variant. Often carried alongside C677T (compound heterozygous), but can also be inherited on its own. A1298C is more associated with neurotransmitter and detox pathway implications. Knowing both variant statuses gives you the full picture.
What it tells youHow it works
Step one
Get your MTHFR test
Choose your test and complete checkout in minutes. You'll receive an instant PDF pathology request to your inbox. No GP visit, no referral needed.
Step two
Walk into any collection centre
Take your referral to any of our 3,300+ Healius partner collection centres across Australia. No booking, no appointment, just walk in. No fasting required for a genetic test.
Step three
Receive your results privately
Your full results report is sent privately to your inbox, typically within 5 to 8 business days. MTHFR is a specialised genetic test processed at a dedicated lab, which takes a bit longer than standard blood tests, but it's still a fraction of the usual GP-and-Medicare route.
Outcome-driven reasons to know your MTHFR status. Each one changes how you spend your money, your effort and your attention.
Methylfolate or folic acid. Methylcobalamin or cyanocobalamin. Stop guessing and start taking the forms your body can actually use.
If your homocysteine is elevated, MTHFR is often the genetic reason. Knowing your variant status reveals what's likely to bring it down.
The MTHFR enzyme runs methylation. Variants reduce that activity by 30 to 70 percent. Knowing your status anchors the rest of your methylation work.
If folic acid or standard B12 isn't doing much for you, MTHFR explains why and reveals what your body actually needs to feel the effect.
MTHFR variants are inherited. One test, lifetime information about how your body handles folate, B12 and homocysteine. Genes don't change.
MTHFR isn't part of routine pathology in Australia. Most people will never know their status unless they go and check. Now you can, without the wait.
A NATA-accredited pathology report showing your C677T and A1298C variant status, with a clinical interpretation. Clear, not buried in jargon.
The same format used by hospitals and GPs across Australia. Delivered privately to your inbox.
C677T and A1298C variant status reported separately, with a combined interpretation of your overall MTHFR enzyme activity.
Secure PDF to your inbox. Share with your GP, naturopath or functional doctor, or act on the data yourself.
One copy of the C677T variant has been detected (heterozygous). This is typically associated with approximately 30 to 40 percent reduced MTHFR enzyme activity, which can affect folate metabolism, B12 utilisation and homocysteine clearance. Consider methylated folate (L-5-MTHF) and methylated B12 (methylcobalamin) supplementation, alongside pairing with a homocysteine test to assess functional impact. Discuss findings with your GP, functional practitioner or specialist for personalised guidance.
We remove the barriers
Private MTHFR blood testing without the GP gatekeeping, the waiting, or the referral hoops.
An overview of what MTHFR is, why the C677T and A1298C variants matter, and what your result means. Written for Australians considering a private MTHFR blood test.
MTHFR stands for methylenetetrahydrofolate reductase, the name of both a gene and the enzyme that gene codes for. The MTHFR enzyme is central to methylation, a biochemical process running constantly in every cell of your body. Methylation is involved in DNA repair, neurotransmitter production, detoxification, energy production and the clearance of homocysteine.
Variants in the MTHFR gene change how efficiently the enzyme works. The two most studied variants are C677T and A1298C. People with one variant copy (heterozygous) typically have 30 to 40 percent reduced enzyme activity. Those with two copies (homozygous) or both variants together (compound heterozygous) can have up to 70 percent reduced activity.
An estimated 1 in 2 Australians carries at least one MTHFR variant. Most never find out, because MTHFR is not part of standard blood testing in Australia.
Reduced MTHFR enzyme activity affects three main areas:
These underlying mechanisms are why MTHFR testing is most commonly sought in a few specific contexts: investigating the cause of unexplained elevated homocysteine in blood work, estimating personal risk when there is a family history of premature heart disease or venous thrombosis (blood clots), investigating recurrent miscarriages or planning ahead with fertility considerations, and personalising B-vitamin and folate supplementation. Less commonly, MTHFR status is also relevant when considering how the body might respond to certain medications, including specific chemotherapy drugs that interact with folate metabolism.
An MTHFR genetic test reports your status for both C677T and A1298C variants. For each, you'll see one of three possible results:
| Status | What it means | Approximate enzyme impact |
|---|---|---|
| Wild type | No variant copies | Normal activity |
| Heterozygous | One variant copy | 30 to 40% reduced |
| Homozygous | Two variant copies | Up to 70% reduced |
If you carry one variant of each (compound heterozygous: C677T heterozygous + A1298C heterozygous), the combined enzyme reduction can be similar to homozygous status. Your report will explain your combined picture.
MTHFR testing is particularly useful for the following groups:
One of the most practical insights from MTHFR testing is whether you should be taking methylfolate (L-5-MTHF) instead of standard folic acid.
Folic acid is the synthetic form of folate found in most cheap supplements and added to fortified foods. Your body needs to convert it into the active form (L-methylfolate) before it can be used. The MTHFR enzyme runs that conversion. With significant MTHFR variants, this conversion can be sluggish, meaning folic acid is poorly utilised and unconverted folic acid may accumulate.
Methylfolate (L-5-MTHF, also known as 5-methyltetrahydrofolate) is the bioavailable form already in active form. People with MTHFR variants typically respond much better to methylfolate than to folic acid. This is one of the most practical and immediately actionable changes that comes from knowing your MTHFR status.
The same logic applies to B12. Methylcobalamin is the active form, preferred over standard cyanocobalamin when MTHFR variants are present.
The MediTests MTHFR Blood Test is a private, self-requested genetic test that you can buy online without a GP referral. The cost is $99, which covers the pathology request, the genetic analysis at a NATA-accredited Australian laboratory, and your results delivered as a secure PDF report.
The process is simple: you complete checkout online and immediately receive a pathology request to your inbox, you walk into any of the 3,300+ Healius collection centres across Australia, a small blood sample is collected (no fasting required), and your results are typically delivered to your inbox within 5 to 8 business days. MTHFR is a specialised genetic test that's processed at a dedicated genetic analysis lab, which is why it takes longer than standard pathology blood tests. Some samples may occasionally take a little longer depending on lab turnaround.
The report includes your C677T and A1298C variant status with a clinical interpretation explaining what your combined result means. The result is yours to share with your GP, naturopath or functional doctor, or to act on yourself when choosing supplements.
Get your private MTHFR blood test today. No GP referral. No appointment. Results typically in 5 to 8 business days.
Get My MTHFR Test, $99Sources & disclaimer
This information is general and educational, not medical advice. MTHFR genetic testing is not routinely recommended by some Australian and international clinical bodies for specific conditions such as thrombophilia screening or recurrent pregnancy loss; it is most commonly used to inform personal folate and B-vitamin choices. Please consult your GP, specialist or qualified healthcare professional for interpretation of your results in your individual clinical context.
Walk into any of 3,300+ collection centres across Australia. No GP. No referral. No appointment. Results typically in 5-8 business days. $99, one-off, no subscription.
Get My MTHFR Test, $99